Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P04000
UPID:
OPSR_HUMAN
Alternative names:
Red cone photoreceptor pigment; Red-sensitive opsin
Alternative UPACC:
P04000
Background:
Long-wave-sensitive opsin 1, also known as Red cone photoreceptor pigment or Red-sensitive opsin, plays a pivotal role in vision. It is a visual pigment that absorbs light, consisting of an apoprotein, opsin, linked to cis-retinal. This protein is essential for the perception of long-wavelength light, contributing to color vision.
Therapeutic significance:
Mutations in Long-wave-sensitive opsin 1 are linked to color vision defects such as partial colorblindness in the protan series and blue cone monochromacy. Understanding the role of Long-wave-sensitive opsin 1 could open doors to potential therapeutic strategies for these visual impairments.