Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P04001
UPID:
OPSG_HUMAN
Alternative names:
Green cone photoreceptor pigment; Green-sensitive opsin
Alternative UPACC:
P04001
Background:
Medium-wave-sensitive opsin 1, also known as Green cone photoreceptor pigment or Green-sensitive opsin, plays a pivotal role in vision by mediating the absorption of light in the medium wavelength range. This protein is a type of visual pigment, consisting of an apoprotein, opsin, covalently linked to cis-retinal, essential for color differentiation.
Therapeutic significance:
Linked to diseases such as Colorblindness, partial, deutan series, Blue cone monochromacy, and Cone dystrophy 5, Medium-wave-sensitive opsin 1's study is crucial. Understanding its role could unveil new therapeutic strategies for these visual impairments.