Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P04179
UPID:
SODM_HUMAN
Alternative names:
-
Alternative UPACC:
P04179; B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3
Background:
Superoxide dismutase [Mn], mitochondrial, identified by the accession number P04179, plays a crucial role in cellular defense. It catalyzes the dismutation of the superoxide anion radical into oxygen and hydrogen peroxide, thereby acting as a primary line of defense against oxidative stress in cells.
Therapeutic significance:
Given its pivotal role in mitigating oxidative damage, the protein is linked to Microvascular complications of diabetes 6, a group of conditions that manifest in various organs due to diabetes mellitus. Understanding the role of Superoxide dismutase [Mn], mitochondrial could open doors to potential therapeutic strategies for these complications.