Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P04746
UPID:
AMYP_HUMAN
Alternative names:
1,4-alpha-D-glucan glucanohydrolase
Alternative UPACC:
P04746; B9EJG1; Q9UBH3
Background:
Pancreatic alpha-amylase, also known as 1,4-alpha-D-glucan glucanohydrolase, plays a crucial role in carbohydrate digestion by breaking down starch into sugars in the human digestive system. This enzyme's activity is essential for the efficient absorption of dietary sugars, making it a key player in human metabolism and energy production.
Therapeutic significance:
Understanding the role of Pancreatic alpha-amylase could open doors to potential therapeutic strategies. Its pivotal function in the digestion process highlights its potential as a target for managing dietary sugar absorption, offering a promising avenue for the development of treatments for metabolic disorders.