Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P05113
UPID:
IL5_HUMAN
Alternative names:
B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor
Alternative UPACC:
P05113; Q13840
Background:
Interleukin-5 (IL-5) is a homodimeric cytokine primarily produced by T-lymphocytes and NK cells. It plays a crucial role in the survival, differentiation, and chemotaxis of eosinophils, as well as influencing B-cell immunoglobulin production, growth, and differentiation. IL-5 functions through the IL5RA and CSF2RB receptor complex, activating kinases like LYN, SYK, and JAK2, which signal through the RAS-MAPK and JAK-STAT5 pathways.
Therapeutic significance:
Understanding the role of Interleukin-5 could open doors to potential therapeutic strategies, particularly in modulating immune responses and treating conditions related to eosinophil function and B-cell activity.