Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P05187
UPID:
PPB1_HUMAN
Alternative names:
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
Alternative UPACC:
P05187; P05188; P06861; Q53S78; Q96DB7
Background:
Alkaline phosphatase, placental type (P05187), also known as Alkaline phosphatase Regan isozyme and Placental alkaline phosphatase 1, plays a crucial role in hydrolyzing various phosphate compounds. Its unique enzymatic activity is pivotal in numerous biological processes, including bone mineralization and the detoxification of compounds.
Therapeutic significance:
Understanding the role of Alkaline phosphatase, placental type could open doors to potential therapeutic strategies. Its enzymatic functions suggest a broad spectrum of applications in disease treatment and prevention, highlighting its importance in medical research.