Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P05787
UPID:
K2C8_HUMAN
Alternative names:
Cytokeratin-8; Keratin-8; Type-II keratin Kb8
Alternative UPACC:
P05787; A8K4H3; B0AZN5; F8VXB4; Q14099; Q14716; Q14717; Q53GJ0; Q6DHW5; Q6GMY0; Q6P4C7; Q96J60
Background:
Keratin, type II cytoskeletal 8, also known as Cytokeratin-8, Keratin-8, and Type-II keratin Kb8, plays a crucial role in the structural integrity of cells. It is particularly significant in linking the contractile apparatus to dystrophin at the costameres of striated muscle, alongside KRT19. This protein's involvement in cellular architecture underscores its importance in maintaining tissue integrity and function.
Therapeutic significance:
Cirrhosis, a severe liver disease characterized by liver-cell swelling, Mallory body formation, and significant copper deposits, is associated with variants affecting the Keratin, type II cytoskeletal 8 gene. Understanding the role of Keratin, type II cytoskeletal 8 in such liver conditions could pave the way for innovative therapeutic strategies, highlighting its potential in disease management and treatment.