Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P07195
UPID:
LDHB_HUMAN
Alternative names:
LDH heart subunit; Renal carcinoma antigen NY-REN-46
Alternative UPACC:
P07195
Background:
The L-lactate dehydrogenase B chain, known alternatively as LDH heart subunit or Renal carcinoma antigen NY-REN-46, plays a crucial role in cellular metabolism. It facilitates the interconversion of pyruvate and lactate with the simultaneous interconversion of NADH and NAD(+), a process vital for maintaining the balance of energy within cells.
Therapeutic significance:
Lactate dehydrogenase B deficiency, a condition linked to this protein, highlights its importance in clinical diagnostics. Although it does not adversely affect health, it can lead to misdiagnosis in conditions where serum LDH levels are a diagnostic marker. Understanding the role of L-lactate dehydrogenase B chain could open doors to potential therapeutic strategies.