Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P07306
UPID:
ASGR1_HUMAN
Alternative names:
C-type lectin domain family 4 member H1; Hepatic lectin H1
Alternative UPACC:
P07306; I3L1X1
Background:
Asialoglycoprotein receptor 1, also known as C-type lectin domain family 4 member H1 or Hepatic lectin H1, plays a crucial role in the endocytosis of plasma glycoproteins by recognizing and binding to terminal galactose and N-acetylgalactosamine units. This process involves the internalization and transport of the receptor-ligand complex to sorting organelles, where they are separated, allowing the receptor to return to the cell surface.
Therapeutic significance:
Understanding the role of Asialoglycoprotein receptor 1 could open doors to potential therapeutic strategies.