Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P07360
UPID:
CO8G_HUMAN
Alternative names:
-
Alternative UPACC:
P07360; Q14CT8; Q14CU0; Q5SQ07
Background:
Complement component C8 gamma chain plays a pivotal role in the immune system's defense mechanism. It is a crucial part of the membrane attack complex (MAC), which targets and eliminates invading pathogens. The protein binds to the C5B-7 complex to form C5B-8, which then acts as a catalyst in the polymerization of C9, leading to the formation of pores in the membrane of the target cell. The gamma subunit's ability to bind retinol highlights its potential multifunctionality within biological systems.
Therapeutic significance:
Understanding the role of Complement component C8 gamma chain could open doors to potential therapeutic strategies. Its involvement in the formation of the membrane attack complex suggests its significance in immune response and its potential as a target for modulating immune activity in diseases.