Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P07550
UPID:
ADRB2_HUMAN
Alternative names:
Beta-2 adrenoreceptor
Alternative UPACC:
P07550; B0LPE4; B2R7X2; O14823; O14824; O14825; O14826; Q4JG18; Q53GA6; Q6GMT4; Q6P4D8; Q8NEQ9; Q96EC3; Q9UCZ0; Q9UCZ1; Q9UCZ2; Q9UCZ3; Q9UH95; Q9UHA1; Q9UMZ5
Background:
The Beta-2 adrenergic receptor, also known as Beta-2 adrenoreceptor, plays a pivotal role in mediating the effects of catecholamines like epinephrine, which it binds with significantly higher affinity compared to norepinephrine. This interaction activates adenylate cyclase through G proteins, a crucial pathway in the cardiovascular and respiratory systems.
Therapeutic significance:
Understanding the role of Beta-2 adrenergic receptor could open doors to potential therapeutic strategies. Its central role in the sympathetic nervous system's response suggests its potential as a target for treating cardiovascular and respiratory conditions.