Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P07602
UPID:
SAP_HUMAN
Alternative names:
Proactivator polypeptide
Alternative UPACC:
P07602; P07292; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742
Background:
Prosaposin, known also as Proactivator polypeptide, plays a crucial role in the lysosomal degradation of sphingolipids, facilitated by its non-enzymic proteins, saposins. These proteins are essential for the hydrolysis of various sphingolipids, acting as activators for specific hydrolases.
Therapeutic significance:
Prosaposin's involvement in diseases such as Combined saposin deficiency, Metachromatic leukodystrophy, Gaucher disease, Krabbe disease, and Parkinson disease 24 highlights its potential as a target for therapeutic strategies. Understanding its role could lead to breakthrough treatments for these lysosomal storage disorders and neurodegenerative diseases.