Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P07948
UPID:
LYN_HUMAN
Alternative names:
Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
Alternative UPACC:
P07948; A0AVQ5
Background:
Tyrosine-protein kinase Lyn, known by its alternative names such as Lck/Yes-related novel protein tyrosine kinase, plays a pivotal role in cell signaling, impacting immune responses, hematopoiesis, and cellular responses to DNA damage. It functions as both an activator and a negative regulator, influencing B-cell differentiation, survival, and apoptosis. Lyn acts downstream of numerous immune receptors and is integral in cytokine and growth factor responses, integrin signaling, and the regulation of cell proliferation and migration.
Therapeutic significance:
Understanding the role of Tyrosine-protein kinase Lyn could open doors to potential therapeutic strategies.