Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P08240
UPID:
SRPRA_HUMAN
Alternative names:
Docking protein alpha
Alternative UPACC:
P08240; A6NIB3; B2R5Z8; B4E0H3; E9PJS4; Q9BVJ4
Background:
Signal recognition particle receptor subunit alpha, also known as Docking protein alpha, plays a pivotal role in protein synthesis and cellular function. It is a key component of the signal recognition particle (SRP) complex receptor, ensuring the accurate targeting of nascent secretory proteins to the endoplasmic reticulum (ER) membrane system. This process is facilitated through a GTP-dependent complex formation with SRP54, driving cotranslational protein translocation into the ER.
Therapeutic significance:
Understanding the role of Signal recognition particle receptor subunit alpha could open doors to potential therapeutic strategies.