Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P08913
UPID:
ADA2A_HUMAN
Alternative names:
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor
Alternative UPACC:
P08913; B0LPF6; Q2I8G2; Q2XN99; Q86TH8; Q9BZK1
Background:
The Alpha-2A adrenergic receptor, also known as Alpha-2 adrenergic receptor subtype C10, plays a crucial role in mediating the catecholamine-induced inhibition of adenylate cyclase via G proteins. This receptor has a specific agonist potency order, highlighting its unique interaction with various compounds, including oxymetazoline and clonidine.
Therapeutic significance:
Understanding the role of Alpha-2A adrenergic receptor could open doors to potential therapeutic strategies. Its involvement in key biochemical pathways underscores its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.