Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P09001
UPID:
RM03_HUMAN
Alternative names:
39S ribosomal protein L3, mitochondrial
Alternative UPACC:
P09001; Q6IBT2
Background:
The Large ribosomal subunit protein uL3m, also known as 39S ribosomal protein L3, mitochondrial, plays a crucial role in mitochondrial protein synthesis. Its involvement in the mitochondrial ribosome underscores its importance in cellular energy production and overall mitochondrial function.
Therapeutic significance:
Combined oxidative phosphorylation deficiency 9, a mitochondrial disease linked to this protein, highlights its critical role in human health. Understanding the role of Large ribosomal subunit protein uL3m could open doors to potential therapeutic strategies for addressing mitochondrial disorders.