Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P09238
UPID:
MMP10_HUMAN
Alternative names:
Matrix metalloproteinase-10; Transin-2
Alternative UPACC:
P09238; B2R9X9; Q53HH9
Background:
Stromelysin-2, also known as Matrix metalloproteinase-10 or Transin-2, plays a crucial role in the degradation of various components of the extracellular matrix, including fibronectin and gelatins of type I, III, IV, and V. Its ability to weakly degrade collagens III, IV, and V and activate procollagenase underscores its importance in tissue remodeling and repair processes.
Therapeutic significance:
Understanding the role of Stromelysin-2 could open doors to potential therapeutic strategies. Its involvement in the breakdown and remodeling of the extracellular matrix suggests a pivotal role in diseases characterized by excessive tissue remodeling or fibrosis.