Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P09455
UPID:
RET1_HUMAN
Alternative names:
Cellular retinol-binding protein; Cellular retinol-binding protein I
Alternative UPACC:
P09455; A8K2Q0; B7Z7A0; E7EWV0; F2Z2F2; Q6FGX8
Background:
Retinol-binding protein 1, also known as Cellular retinol-binding protein and Cellular retinol-binding protein I, plays a crucial role in the intracellular transport of vitamin A. It is a cytoplasmic protein that accepts retinol from STRA6, a membrane receptor, facilitating retinol uptake, storage, and overall retinoid homeostasis. This process is vital for vision, growth, reproduction, and immune function.
Therapeutic significance:
Understanding the role of Retinol-binding protein 1 could open doors to potential therapeutic strategies.