Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P09471
UPID:
GNAO_HUMAN
Alternative names:
-
Alternative UPACC:
P09471; P29777; Q8TD72; Q9UMV4
Background:
The Guanine nucleotide-binding protein G(o) subunit alpha plays a pivotal role in cellular signaling as a modulator or transducer in various transmembrane signaling systems. Its interaction with RGS14 suggests a complex regulatory mechanism, highlighting its significance in cellular communication.
Therapeutic significance:
Linked to severe neurological disorders such as Developmental and epileptic encephalopathy 17 and Neurodevelopmental disorder with involuntary movements, understanding the role of Guanine nucleotide-binding protein G(o) subunit alpha could open doors to potential therapeutic strategies.