Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P09525
UPID:
ANXA4_HUMAN
Alternative names:
35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PP4-X; Placental anticoagulant protein II; Protein II
Alternative UPACC:
P09525; B4DDF9; Q6LES2; Q96F33; Q9BWK1
Background:
Annexin A4, known by alternative names such as Annexin IV and Lipocortin IV, is a calcium/phospholipid-binding protein pivotal in promoting membrane fusion and facilitating exocytosis. This protein's diverse aliases, including 35-beta calcimedin and Placental anticoagulant protein II, reflect its multifunctionality across various biological processes.
Therapeutic significance:
Understanding the role of Annexin A4 could open doors to potential therapeutic strategies. Its involvement in membrane fusion and exocytosis underlines its importance in cellular processes, suggesting that targeting Annexin A4 could offer novel approaches in drug discovery.