Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P09848
UPID:
LPH_HUMAN
Alternative names:
Lactase/glycosylceramidase
Alternative UPACC:
P09848; Q4ZG58
Background:
Lactase/phlorizin hydrolase, also known as Lactase/glycosylceramidase, plays a crucial role in the digestion of lactose, the primary sugar in mammalian milk. It hydrolyzes lactose into D-glucose and D-galactose, facilitating nutrient absorption in the intestinal brush border membrane. This enzyme exhibits broad specificity, targeting beta-glucopyranosides and beta-galactopyranosides with varying preferences for aglycone moieties.
Therapeutic significance:
Congenital lactase deficiency, a rare gastrointestinal disorder marked by severe diarrhea in infants, underscores the enzyme's critical function. This condition, alongside lactose intolerance, highlights the enzyme's potential in therapeutic strategies aimed at managing lactase activity levels and improving gastrointestinal health.