Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P09919
UPID:
CSF3_HUMAN
Alternative names:
Pluripoietin
Alternative UPACC:
P09919; A8MXR7
Background:
Granulocyte colony-stimulating factor (G-CSF), also known as Pluripoietin, is a pivotal cytokine in hematopoiesis. It orchestrates the production, differentiation, and function of granulocytes and monocytes-macrophages, two crucial white cell populations in the blood. This protein's ability to induce granulocytes highlights its essential role in maintaining the body's defense mechanisms.
Therapeutic significance:
Understanding the role of Granulocyte colony-stimulating factor could open doors to potential therapeutic strategies. Its critical function in blood cell regulation positions it as a key target for interventions in diseases where the immune response is compromised or needs modulation.