Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P0DJR0
UPID:
GIMD1_HUMAN
Alternative names:
GIMAP family P-loop NTPase domain-containing protein 1
Alternative UPACC:
P0DJR0
Background:
GTPase IMAP family member GIMD1, also known as GIMAP family P-loop NTPase domain-containing protein 1, plays a crucial role in cellular processes through its GTPase activity. This protein is part of the GIMAP family, which is involved in the regulation of cell survival and apoptosis in immune cells. The specific functions of GIMD1 within this family and its broader biological roles remain to be fully elucidated.
Therapeutic significance:
Understanding the role of GTPase IMAP family member GIMD1 could open doors to potential therapeutic strategies. Its involvement in cell survival and apoptosis, particularly in immune cells, suggests that it could be a target for modulating immune responses in various diseases.