Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P0DML2
UPID:
CSH1_HUMAN
Alternative names:
Lactogen; Placental lactogen
Alternative UPACC:
P0DML2; P01243; Q0VDB1; Q14407
Background:
Chorionic somatomammotropin hormone 1, also known as Lactogen or Placental lactogen, plays a pivotal role in pregnancy. It is exclusively produced during this period, contributing significantly to lactation, fetal growth, and metabolism. Unlike its interaction with GHR, it uniquely activates PRLR through zinc-induced dimerization.
Therapeutic significance:
Understanding the role of Chorionic somatomammotropin hormone 1 could open doors to potential therapeutic strategies. Its exclusive production during pregnancy and unique mechanism of action highlight its importance in maternal and fetal health.