Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P0DML3
UPID:
CSH2_HUMAN
Alternative names:
Lactogen; Placental lactogen
Alternative UPACC:
P0DML3; P01243; Q0VDB1; Q14407
Background:
Chorionic somatomammotropin hormone 2, also known as Lactogen or Placental lactogen, plays a pivotal role in pregnancy. It is exclusively produced during this period, contributing significantly to lactation, fetal growth, and metabolism. Unlike its interaction with GHR, it uniquely activates PRLR through a zinc-induced dimerization process.
Therapeutic significance:
Understanding the role of Chorionic somatomammotropin hormone 2 could open doors to potential therapeutic strategies. Its exclusive production during pregnancy and unique mechanism of action highlight its importance in maternal and fetal health.