Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P0DMV9
UPID:
HS71B_HUMAN
Alternative names:
Heat shock 70 kDa protein 2
Alternative UPACC:
P0DMV9; B4E3B6; P08107; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0
Background:
Heat shock 70 kDa protein 1B, also known as Heat shock 70 kDa protein 2, plays a crucial role in cellular processes including protein folding, stress response, and proteolysis of misfolded proteins. It operates through ATP binding and hydrolysis, influenced by co-chaperones, to ensure protein quality control. Its function is modulated by its nucleotide-bound state, affecting its affinity for substrate proteins.
Therapeutic significance:
Understanding the role of Heat shock 70 kDa protein 1B could open doors to potential therapeutic strategies.