Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P10266
UPID:
POK10_HUMAN
Alternative names:
HERV-K10 Pol protein; HERV-K107 Pol protein; HERV-K_5q33.3 provirus ancestral Pol protein
Alternative UPACC:
P10266; P87890; Q14273
Background:
The Endogenous retrovirus group K member 10 Pol protein, with alternative names such as HERV-K10 Pol protein, HERV-K107 Pol protein, and HERV-K_5q33.3 provirus ancestral Pol protein, plays a crucial role in the early stages of infection. It converts viral RNA into double-stranded DNA and facilitates its integration into the host cell chromosome, a process pivotal for viral replication and pathogenesis.
Therapeutic significance:
Understanding the role of Endogenous retrovirus group K member 10 Pol protein could open doors to potential therapeutic strategies.