Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P10606
UPID:
COX5B_HUMAN
Alternative names:
Cytochrome c oxidase polypeptide Vb
Alternative UPACC:
P10606; Q53YB7; Q96J18; Q99610
Background:
Cytochrome c oxidase subunit 5B, mitochondrial, also known as Cytochrome c oxidase polypeptide Vb, plays a crucial role in the mitochondrial electron transport chain. It is a key component of cytochrome c oxidase, the enzyme responsible for the reduction of oxygen to water, a process vital for ATP synthesis. This protein facilitates the transfer of electrons from cytochrome c to the active site, contributing to the electrochemical gradient essential for energy production.
Therapeutic significance:
Understanding the role of Cytochrome c oxidase subunit 5B, mitochondrial could open doors to potential therapeutic strategies.