Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P10643
UPID:
CO7_HUMAN
Alternative names:
-
Alternative UPACC:
P10643; A8K2T4; Q6P3T5; Q92489
Background:
Complement component C7 is a crucial part of the membrane attack complex (MAC), playing a pivotal role in both innate and adaptive immunity. It functions by anchoring to the plasma membrane of target cells, facilitating the formation of pores that lead to cell lysis.
Therapeutic significance:
Complement component 7 deficiency, a rare genetic disorder, highlights the protein's significance. This condition leads to increased susceptibility to severe infections, especially by Neisseria species. Understanding C7's role could pave the way for innovative treatments targeting these infections.