Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P10912
UPID:
GHR_HUMAN
Alternative names:
Somatotropin receptor
Alternative UPACC:
P10912; Q9HCX2
Background:
The Growth Hormone Receptor (GHR), also known as Somatotropin receptor, plays a pivotal role in regulating postnatal body growth. It functions by binding to the pituitary gland growth hormone, activating the JAK2/STAT5 pathway. Additionally, its soluble form (GHBP) serves as a growth hormone reservoir in plasma, potentially modulating GH signaling.
Therapeutic significance:
GHR is implicated in Laron syndrome and partial growth hormone insensitivity, both of which involve growth impairment and short stature due to dysfunctional GHR. Understanding the role of Growth Hormone Receptor could open doors to potential therapeutic strategies for these conditions.