Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P11215
UPID:
ITAM_HUMAN
Alternative names:
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Alternative UPACC:
P11215; Q4VAK0; Q4VAK1; Q4VAK2
Background:
Integrin alpha-M, also known as CD11 antigen-like family member B, plays a pivotal role in the immune system. It facilitates adhesive interactions of monocytes, macrophages, and granulocytes, crucial for pathogen clearance and immune response. As a receptor for various ligands, including the iC3b fragment of the third complement component, fibrinogen, and ICAM1, it mediates uptake of complement-coated particles and regulates neutrophil migration and apoptosis.
Therapeutic significance:
Given its involvement in systemic lupus erythematosus 6, a disorder characterized by autoimmune dysregulation affecting multiple systems, Integrin alpha-M represents a potential target for therapeutic intervention. Understanding its regulatory mechanisms in autoimmune responses could lead to novel treatments for systemic lupus erythematosus and other inflammatory diseases.