Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P11908
UPID:
PRPS2_HUMAN
Alternative names:
PPRibP; Phosphoribosyl pyrophosphate synthase II
Alternative UPACC:
P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7
Background:
Ribose-phosphate pyrophosphokinase 2 (Ribose-PPK2), also known as PPRibP or Phosphoribosyl pyrophosphate synthase II, plays a pivotal role in nucleotide synthesis by catalyzing the formation of phosphoribosylpyrophosphate (PRPP). PRPP is a critical precursor for the biosynthesis of purines and pyrimidines, essential components of DNA and RNA.
Therapeutic significance:
Understanding the role of Ribose-phosphate pyrophosphokinase 2 could open doors to potential therapeutic strategies. Its fundamental involvement in nucleotide synthesis makes it a potential target for developing treatments for conditions where nucleotide balance is disrupted.