Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P12018
UPID:
VPREB_HUMAN
Alternative names:
CD179 antigen-like family member A; Protein VPreB1; V(pre)B protein
Alternative UPACC:
P12018; B5MCG2
Background:
The Immunoglobulin iota chain, known alternatively as CD179 antigen-like family member A, Protein VPreB1, or V(pre)B protein, plays a crucial role in early B-cell differentiation. It forms a molecular complex with the Ig-mu chain, expressed on the surface of pre-B-cells, which is essential for regulating Ig gene rearrangements.
Therapeutic significance:
Understanding the role of the Immunoglobulin iota chain could open doors to potential therapeutic strategies, particularly in modulating the immune system's response and enhancing vaccine efficacy.