Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P13535
UPID:
MYH8_HUMAN
Alternative names:
Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal
Alternative UPACC:
P13535; Q14910
Background:
Myosin-8, also known as Myosin heavy chain 8 and Myosin heavy chain, skeletal muscle, perinatal, plays a crucial role in muscle contraction. This protein's involvement in the fundamental process of muscle contraction highlights its importance in muscular movement and stability.
Therapeutic significance:
Myosin-8's association with diseases such as Carney complex variant and Arthrogryposis, distal, 7, underscores its potential in therapeutic strategies. Understanding the role of Myosin-8 could open doors to potential therapeutic strategies for these conditions, emphasizing the need for further research into its functions and mechanisms.