Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P13631
UPID:
RARG_HUMAN
Alternative names:
Nuclear receptor subfamily 1 group B member 3
Alternative UPACC:
P13631; B7Z492; B7Z4F1; B7ZAE4; J3KNP6; P22932; Q15281; Q52LZ8; Q9BYX8; Q9H1I3; Q9UJ38
Background:
Retinoic acid receptor gamma, a member of the nuclear receptor subfamily 1 group B, plays a pivotal role in mediating the effects of retinoic acid. This receptor binds as heterodimers to retinoic acid response elements, regulating gene expression in processes such as limb bud development and skeletal growth. Its interaction with ligands like all-trans or 9-cis retinoic acid highlights its significance in matrix homeostasis and growth plate function.
Therapeutic significance:
Understanding the role of Retinoic acid receptor gamma could open doors to potential therapeutic strategies.