Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P13796
UPID:
PLSL_HUMAN
Alternative names:
L-plastin; LC64P; Lymphocyte cytosolic protein 1
Alternative UPACC:
P13796; B2R613; B4DUA0; Q5TBN4
Background:
Plastin-2, also known as L-plastin, LC64P, and Lymphocyte cytosolic protein 1, is a crucial actin-binding protein. It plays a pivotal role in T-cell activation through TCR/CD3 and CD2 or CD28, influencing the cell surface expression of IL2RA/CD25 and CD69. This protein's involvement in the immune response highlights its significance in cellular functions.
Therapeutic significance:
Understanding the role of Plastin-2 could open doors to potential therapeutic strategies. Its critical function in T-cell activation and modulation of cell surface markers makes it a promising target for modulating immune responses in various diseases.