Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P13797
UPID:
PLST_HUMAN
Alternative names:
T-plastin
Alternative UPACC:
P13797; A8K579; B1AQ09; B4DGB4; B7Z6M1; Q86YI6
Background:
Plastin-3, also known as T-plastin, is an actin-bundling protein prevalent in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. Its role is crucial in the structural integrity and function of these cellular extensions, suggesting a significant impact on cellular morphology and motility.
Therapeutic significance:
Given its involvement in bone development regulation, Plastin-3's study is pivotal in understanding osteoporosis—a condition marked by decreased bone mass and increased fracture risk. Understanding the role of Plastin-3 could open doors to potential therapeutic strategies for osteoporosis, aiming at enhancing bone density and reducing fracture susceptibility.