Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P13942
UPID:
COBA2_HUMAN
Alternative names:
-
Alternative UPACC:
P13942; A6NLX2; E7ER90; Q07751; Q13271; Q13272; Q13273; Q5JP94; Q5SUI8; Q7Z6C3; Q99866; Q9UIP9
Background:
The Collagen alpha-2(XI) chain plays a pivotal role in the formation of collagen II fibrils, essential for maintaining the structural integrity of cartilage and connective tissue. This protein's involvement in fibrillogenesis suggests its critical function in skeletal development and maintenance.
Therapeutic significance:
Linked to various skeletal dysplasias and hearing loss conditions, the Collagen alpha-2(XI) chain's genetic variants illuminate its significance in otospondylomegaepiphyseal dysplasia, both autosomal dominant and recessive forms, and specific types of deafness. Understanding its role could lead to breakthroughs in treating these debilitating conditions.