Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P14416
UPID:
DRD2_HUMAN
Alternative names:
Dopamine D2 receptor
Alternative UPACC:
P14416; Q9NZR3; Q9UPA9
Background:
The D(2) dopamine receptor, also known as the Dopamine D2 receptor, plays a crucial role in the central nervous system. Its activity is mediated by G proteins which inhibit adenylyl cyclase. This receptor is also involved in the postnatal regression of retinal hyaloid vessels, acting through the suppression of VEGFR2/KDR activity, a process suggested to be downstream of OPN5.
Therapeutic significance:
Understanding the role of the D(2) dopamine receptor could open doors to potential therapeutic strategies. Its involvement in neurotransmission and vascular processes highlights its importance in neurobiology and ophthalmology.