Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P14868
UPID:
SYDC_HUMAN
Alternative names:
Aspartyl-tRNA synthetase; Cell proliferation-inducing gene 40 protein
Alternative UPACC:
P14868; A8K3J2; D3DP77; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52
Background:
Aspartate--tRNA ligase, cytoplasmic, also known as Aspartyl-tRNA synthetase and Cell proliferation-inducing gene 40 protein, plays a crucial role in protein synthesis. It catalyzes the attachment of aspartate to its cognate tRNA, a fundamental process for accurate translation of the genetic code into functional proteins.
Therapeutic significance:
The protein is linked to Hypomyelination with brainstem and spinal cord involvement and leg spasticity, a severe neurological disorder. Understanding the role of Aspartate--tRNA ligase, cytoplasmic could open doors to potential therapeutic strategies for this debilitating condition.