Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P15086
UPID:
CBPB1_HUMAN
Alternative names:
Pancreas-specific protein
Alternative UPACC:
P15086; O60834; Q53XJ0; Q96BQ8
Background:
Carboxypeptidase B, also known as Pancreas-specific protein, plays a crucial role in protein digestion by removing terminal amino acids from the peptide chain. This enzyme, encoded by the gene with the accession number P15086, is predominantly expressed in the pancreas and is essential for the proper breakdown and absorption of dietary proteins.
Therapeutic significance:
Understanding the role of Carboxypeptidase B could open doors to potential therapeutic strategies. Its pivotal function in protein metabolism suggests that modulating its activity could have implications for conditions related to protein digestion and absorption.