Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P15151
UPID:
PVR_HUMAN
Alternative names:
Nectin-like protein 5
Alternative UPACC:
P15151; B4DTS9; P15152; Q15267; Q15268; Q96BJ1
Background:
The Poliovirus receptor, also known as Nectin-like protein 5, plays a crucial role in immune defense. It mediates NK cell adhesion, triggering effector functions crucial for the immune response. This protein is pivotal in forming a mature immunological synapse, facilitating adhesion, secretion of lytic granules, and IFN-gamma, which are vital for activated NK cells' cytotoxicity. Additionally, it serves as a receptor for various microbial infections, including poliovirus and Pseudorabies virus, and is involved in mechanisms of immunoevasion by tumor cells.
Therapeutic significance:
Understanding the role of the Poliovirus receptor could open doors to potential therapeutic strategies, particularly in enhancing immune response against tumor cells and microbial infections.