Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P15328
UPID:
FOLR1_HUMAN
Alternative names:
Adult folate-binding protein; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18
Alternative UPACC:
P15328; Q53EW2; Q6FGT8; Q6LC90; Q9UCT2
Background:
Folate receptor alpha, known by alternative names such as Adult folate-binding protein and Ovarian tumor-associated antigen MOv18, plays a crucial role in cellular functions. It binds to folate and reduced folic acid derivatives, facilitating the delivery of these essential nutrients into cells. This receptor is pivotal for normal embryonic development and cell proliferation.
Therapeutic significance:
The protein is linked to Neurodegeneration due to cerebral folate transport deficiency, a severe neurodegenerative disorder. Understanding the role of Folate receptor alpha could open doors to potential therapeutic strategies for this and related diseases.