Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P17752
UPID:
TPH1_HUMAN
Alternative names:
Tryptophan 5-monooxygenase 1
Alternative UPACC:
P17752; D3DQX6; O95188; O95189; Q16736; Q3KPG8
Background:
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, plays a pivotal role in serotonin biosynthesis. It catalyzes the conversion of L-tryptophan to 5-hydroxy-l-tryptophan, a critical step in the production of serotonin, a neurotransmitter essential for maintaining mood balance.
Therapeutic significance:
Understanding the role of Tryptophan 5-hydroxylase 1 could open doors to potential therapeutic strategies. Its central function in serotonin production makes it a target of interest in the treatment of disorders related to serotonin imbalance, such as depression and anxiety.