Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P17948
UPID:
VGFR1_HUMAN
Alternative names:
Fms-like tyrosine kinase 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular permeability factor receptor
Alternative UPACC:
P17948; A3E342; A3E344; A8KA71; B0LPF1; B2BF46; B2BF47; B2BF48; B3FR89; B5A923; F5H5L6; O60722; P16057; Q12954
Background:
Vascular endothelial growth factor receptor 1 (VEGFR-1), also known as Fms-like tyrosine kinase 1, plays a pivotal role in angiogenesis, cell survival, and migration. It acts as a cell-surface receptor for VEGFA, VEGFB, and PGF, crucial for embryonic vasculature development and postnatal retinal vessel regression. VEGFR-1 has a unique function in regulating angiogenesis by modulating endothelial cell proliferation and forming heterodimers with KDR, influencing various signaling pathways including PLCG, MAPK, and AKT1.
Therapeutic significance:
Understanding the role of Vascular endothelial growth factor receptor 1 could open doors to potential therapeutic strategies.