Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P18754
UPID:
RCC1_HUMAN
Alternative names:
Cell cycle regulatory protein; Chromosome condensation protein 1
Alternative UPACC:
P18754; Q16269; Q6NT97
Background:
The Regulator of chromosome condensation (P18754) is pivotal in RAN-mediated nuclear import and mitosis, facilitating the exchange of Ran-bound GDP for GTP. This protein ensures the presence of GTP-bound RAN, crucial for mitotic spindle assembly and progression through mitosis. It also plays a role in the release of cargo proteins post-nuclear import and is involved in the early stages of chromosome condensation.
Therapeutic significance:
Understanding the role of the Regulator of chromosome condensation could open doors to potential therapeutic strategies.