Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P19883
UPID:
FST_HUMAN
Alternative names:
Activin-binding protein
Alternative UPACC:
P19883; B5BU94; Q9BTH0
Background:
Follistatin, also known as Activin-binding protein, plays a crucial role in regulating the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by binding directly to activin, acting as its antagonist. This protein's unique function in hormonal regulation underscores its importance in reproductive biology and endocrinology.
Therapeutic significance:
Understanding the role of Follistatin could open doors to potential therapeutic strategies. Its ability to modulate activin and FSH levels suggests its utility in treating conditions related to reproductive health and hormonal imbalances.