Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P20142
UPID:
PEPC_HUMAN
Alternative names:
Pepsinogen C
Alternative UPACC:
P20142; B4DVZ3; Q5T3D7; Q5T3D8
Background:
Gastricsin, also known as Pepsinogen C, is an enzyme that plays a crucial role in the digestive system by hydrolyzing a variety of proteins. This process is essential for the breakdown of dietary proteins into peptides and amino acids, facilitating their absorption in the digestive tract. Gastricsin operates optimally in the acidic environment of the stomach, contributing to the initial stages of protein digestion.
Therapeutic significance:
Understanding the role of Gastricsin could open doors to potential therapeutic strategies. Its pivotal function in protein digestion makes it a key target for addressing digestive disorders and improving nutrient absorption. By exploring Gastricsin's mechanism of action, researchers can develop novel treatments that enhance or regulate protein digestion, potentially benefiting individuals with digestive impairments.