Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P20701
UPID:
ITAL_HUMAN
Alternative names:
CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain
Alternative UPACC:
P20701; O43746; Q45H73; Q96HB1; Q9UBC8
Background:
Integrin alpha-L, also known as CD11 antigen-like family member A, plays a pivotal role in immune response mechanisms. This protein facilitates crucial processes such as leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody-dependent killing by granulocytes and monocytes. It is integral to leukocyte adhesion, transmigration, and the generation of lymphoid progenitor cells, underscoring its importance in lymphopoiesis and immune surveillance.
Therapeutic significance:
Understanding the role of Integrin alpha-L could open doors to potential therapeutic strategies. Its involvement in immune cell functions and interactions makes it a promising target for modulating immune responses, potentially leading to breakthroughs in treating inflammatory and autoimmune diseases.