Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P20702
UPID:
ITAX_HUMAN
Alternative names:
CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95
Alternative UPACC:
P20702; Q8IVA6
Background:
Integrin alpha-X, also known as CD11 antigen-like family member C, plays a pivotal role in the immune system. It functions as a receptor for fibrinogen, recognizing the sequence G-P-R, which is crucial for mediating cell-cell interactions during inflammatory responses. This protein is particularly significant in monocyte adhesion and chemotaxis, highlighting its importance in the body's defense mechanisms.
Therapeutic significance:
Understanding the role of Integrin alpha-X could open doors to potential therapeutic strategies. Its involvement in cell adhesion and immune response regulation makes it a promising target for developing treatments aimed at inflammatory diseases and immune system disorders.